i Bloodindex - Granulocyte Transfusion
Bloodindex - Home
Search Bloodindex
Login Name :
Password :
 Dear Guest, Welcome to Bloodindex Sign in | Sign up

My health diary Health Diary - An Online Electronic Personal Health Record Solution

My health folder Health folder

Blood sugar diary Blood sugar diary

BP printable diary Blood pressure report charts and diary

Cholestrol diary Cholestrol Report Diary

Clinical tests diary Customizable Clinical Tests Diary

Treatment diary Treatment follow up diary

Directory service Directory Service

Knowledge zone knowledge Service

Download zone Download Center

Health calculators Health Calculators

News zone News Zone

Tell my friend Tell My Friend

Blood services Blood Services

Support services Download Center

Link map Download Center

Diabetes Zone - Comprehensive detailed information on Diabetes

My Health Folder

bloodindex AIDS zone

HIV/AIDS care community

Granulocyte Transfusion

You are here : Home/ Blood Bank Zone/ Blood Transfusion in Clinical Practice/ 4. Granulocyte Transfusion

4. Granulocyte Transfusion

When transfused to patients with severe neutropenia and infection, granulocytes can to combat infection. Granulocyte therapy is difficult as neutrophils represent only a very small fraction of the formed element and have a very short survival. Granulocytes have a very short shelf-life and they should be transfused within 12 hours.

Granulocyte Preparations

Granulocyte can be prepared from a whole blood unit collected into triple interconnected bags or alternatively blood cell seperator may be used to collect granulocytes directly from a donor.


Indications for granulocyte transfusion are limited to carefully selected cases in which possible benefits are thought to outweight the considerable hazards. Few of the specific indications are as follows:

1. Absolute neutrophil count less than 0.2 x 10/1 (200/ui)
2. Neonates with bacterial sepsis
3. Severe persistent neutropenia and infections
4. Abnormal neutrophil function and persistent infection

Granulocytes given to newborn infants must be irradiated to prevent graft versus hot disease.


For therapeutic purposes at least 1 X 10^10 functioning granulocytes should be transfused which is equivalent to one donation on cell separator or huffy coat collected from 12-18 single units of whole blood. Therapy should continue for 4-7 days before reassessing the position. in neonates 0.2 x 1010 granulocytes 12 hourly should be infused for 3-4 days.

Role of Granulocyte Transfusion

Routine use of granulocyte transfusion is controversial due to the problems associated with collection of granulocytes, along with serious transfusion reactions which follow transfusion of granulocytes. Availability of recombinant haematopoletic growth factors (GM-CSF, G-CSF) has reduced the role of granulocyte transfusion in clinical practice.

Blood bank zone Next Articles
  1. Blood Transfusion in Clinical Practice - Introduction
  2. Transfusion of Red Cells
  3. Platelet Transfusion
  4. Granulocyte Transfusion
  5. Transfusion of Plasma and its -Components
  6. Massive Blood Transfusion
  7. Haemostasis and component treatment
  8. Multiple Transfusions
  9. Autologous Blood Transfusion
  10. Practical Aspects of Administration of Blood
You are here : Home/ Blood Bank Zone/ Preservation Storage Transportation of Blood / 4. Granulocyte Transfusion

Find nutrition values for common foods
Bloodindex - Blood pressure diary, reports and charts
Events | About us | Link to us | Contact us | Associates | Services | Fund-rising options | Feedback | Privacy policy | Disclaimer | RSS feed
© 2007 bloodindex